We invent novel optical probes–luminescent nanocrystals and organic fluorophores–as biosensors and single-molecule probes, develop bioconjugation and targeting chemistries, and image live cells  with these reagents.  We aim to use interesting and unusual new luminescent nanomaterials to address  fundamental questions of cell function. 

Check out our new Nature cover on photon avalanching nanoparticles and our Covid19 sensor project.  

Left:  Fluorescent tarantula toxins for studying ion channel structure.  Center: Upconverting nanoparticles made into lasers smaller than a cell. Right: ANPs for deeply subwavelength imaging.

                                       We’re based at the Molecular Foundry at Berkeley Lab.  See our amazing view of Berkeley and San Francisco live here.