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We invent novel optical probes–luminescent nanocrystals and organic fluorophores–as biosensors and single-molecule probes, develop bioconjugation and targeting chemistries, and image live cells  with these reagents.  We aim to use interesting and unusual new luminescent nanomaterials to address  fundamental questions of cell function.  Above:  Copper ions catalyze bioconjugation of tarantula toxins to a quantum dot without quenching it, described in Mann et al., ACS Nano 12, 4469–4477 (2018).

                                       We’re based at the Molecular Foundry at Berkeley Lab.  See our amazing view of Berkeley and San Francisco live here.